It is conceivable to get dengue more than once. Dengue is caused by an infection which has four distinct strains.Being influenced by one pressure offers no insurance against the others. A man can experience the ill effects of dengue more than once in her/his lifetime.

Armies could be overpowered if they don't adapt to another enemy. The immune system gets the same error when combating recurrent spells of dengue fever, according to another study. The outcomes could help researchers create a much-needed vaccine to protect against the prevalent mosquito-borne tropical disease.

The majority of the over 50 million individuals sickened by dengue virus annually create dengue fever, a week-long bout of muscle and joint pain. But most who suffer duplicate infections have it even worse. Oddly, the virus causing dengue fever comes in several breeds, and resistance to one appears to earn disease by another strain more harmful. The going theory for that--which antibodies produced by a first bout with dengue bind into another twist, which assists it to multiply from the immune cells--does not account for its internal bleeding, and tissue damage states Juthathip Mongkolsapaya of Mahidol University in Bangkok, Thailand.

To discover, they analyzed T cells in blood samples in 71 children with dengue fever or dengue hemorrhagic fever. In test tube experiments, then they connected virus fragments to individual cell proteins; including this complex into the T cells stimulated them to combat the virus. By analyzing the way the T cells reacted, the team discovered that the cells had been primed to tackle a different breed than the one attacking them.

What is more, the dengue-specific T cells have been quickly self-destructing--a reaction that could result in tissue damage, based on results reported in the July problem of Nature Medication. The resistant misfiring and consequent cell suicide, Mongkolsapaya states, could be the main reason for dengue hemorrhagic fever. Similar experiments may currently have the ability to discover other parasitic virus fragments that together could compose a vaccine that arouses a protective immune reaction.